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Infant gut microbiota contributes to cognitive performance in mice
dc.contributor.author | Cerdó, Tomás | |
dc.contributor.author | Ruiz Rodríguez, Alicia | |
dc.contributor.author | Acuña Morales, Inmaculada | |
dc.contributor.author | Torres Espínola, Francisco José | |
dc.contributor.author | Menchén Márquez, Sergio | |
dc.contributor.author | Gámiz Ruiz, Fernando | |
dc.contributor.author | Gallo Torre, Milagros | |
dc.contributor.author | Jehmlich, Nico | |
dc.contributor.author | Haange, Sven-Bastiaan | |
dc.contributor.author | Von Bergen, Martin | |
dc.contributor.author | Campoy Folgoso, Cristina | |
dc.contributor.author | Suárez García, Antonio Francisco | |
dc.date.accessioned | 2024-01-12T13:33:57Z | |
dc.date.available | 2024-01-12T13:33:57Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Published version: Cerdó, Tomás et al. Infant gut microbiota contributes to cognitive performance in mice. Cell Host Microbe. 2023. Dec 13;31(12):1974-1988.e4. [doi: 10.1016/j.chom.2023.11.004] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/86758 | |
dc.description | Work in the author’s laboratories was performed on resources provided by the Spanish Health and Science Ministries (PREOBE project P06-CTS-02341, BFU2012-40254-C03-01, and PID2020-114269GB-I00), Junta de Andalucía, and UFZ-Germany. T.C. participated in the PhD program in biomedicine at UGR, was a fellowship of the FPI program (BES-2013-065133) funded by the Spanish Ministry of Economy and Competitiveness, and is currently supported by the ‘‘Sara Borrell’’ program (CD21/00187) of the Carlos III Institute. I.A., S.M.-M., and A.R.-R. were granted PhD scholarships (FPU) from the Spanish Ministry of Economy and Competitiveness. A.R.-R. currently holds a María Zambrano Next Generation EU-Talent Reincorporation from UGR. | es_ES |
dc.description.abstract | Gut microbiota has been related to infant neurodevelopment. Here, an association between infant composite cognition with gut microbiota composition was established as soon as 6 months. Higher diversity and evenness characterized microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses established an association between microbial histidine ammonia lyase activity and infant histidine metabolome with cognition. Fecal transplantation from Inf-aboveCC versus Inf-belowCC donors into germ-free mice showed that memory, assessed by novel object recognition test, was a transmissible trait. Furthermore, Inf-aboveCC mice were enriched in species previously linked to cognition belonging to Bacteroides, Phaeicola and Bifidobacterium. Finally, Inf-aboveCC mice showed differential faecal histidine, hippocampal urocanate and histidine-urocanate-glutamate ratios compared to Inf-aboveCC mice. Overall, these findings reveal a causative role of gut microbiota on infant cognition pointing at modulation of histidine metabolite levels as a potential underlying mechanism. | es_ES |
dc.description.sponsorship | Spanish Health and Science Ministries (PREOBE project P06-CTS-02341, BFU2012-40254-C03-01, PID2020-114269GB-I00) | es_ES |
dc.description.sponsorship | Junta de Andalucía | es_ES |
dc.description.sponsorship | UFZ-Germany | es_ES |
dc.description.sponsorship | Spanish Ministry of Economy and Competitiveness BES-2013-065133 | es_ES |
dc.description.sponsorship | Carlos III Institute (CD21/00187) | es_ES |
dc.description.sponsorship | María Zambrano Next Generation EU-Talent Reincorporation | es_ES |
dc.description.sponsorship | UGR | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cognition | es_ES |
dc.subject | Germ-free mice | es_ES |
dc.subject | Gut | es_ES |
dc.subject | Histidine metabolome | es_ES |
dc.subject | Infant | es_ES |
dc.subject | Microbiota | es_ES |
dc.subject | Metaproteomics | es_ES |
dc.title | Infant gut microbiota contributes to cognitive performance in mice | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.1016/j.chom.2023.11.004 | |
dc.type.hasVersion | SMUR | es_ES |