Activity, structural features and in silico digestion of antidiabetic peptides
Metadatos
Mostrar el registro completo del ítemAutor
Berraquero García, Carmen; Rivero Pino, Fernando; Ospina, J. Lizeth; Pérez Gálvez, Antonio Raúl; Espejo Carpio, Francisco Javier; Guadix Escobar, Antonio María; García Moreno, Pedro Jesús; Guadix Escobar, Emilia MaríaEditorial
Elsevier
Materia
Antidiabetic peptides DPP-IV α-glucosidase α-amylase
Fecha
2023-10Referencia bibliográfica
C. Berraquero-García et al. Activity, structural features and in silico digestion of antidiabetic peptides. Food Bioscience 55 (2023) 102954. [https://doi.org/10.1016/j.fbio.2023.102954]
Patrocinador
MCIN/AEI/10.13039/501100011033: PID2020-114137RB-I00Resumen
Food antidiabetic peptides inhibit the enzymes involved in the regulation of the glycemic index (e.g. a-amylase, a-glucosidase and dipeptidyl peptidase-IV (DPP-IV)). This work reviews the antidiabetic peptide sequences reported in the literature, with activity confirmed by using synthetic peptides, and critically discusses their structural features. Moreover, it provides an overview of the potency of in silico analysis tools to predict the in vitro antidiabetic activity of DPP-IV-inhibitory peptides. In addition, the potential degradation of the most active peptides during digestion was evaluated in silico. Therefore, this work advances our understanding on the structure-activity relationship of antidiabetic peptides and provides new insights on their stability during digestion.