Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
Metadatos
Mostrar el registro completo del ítemAutor
Pérez Florido, Javier; Ortuño Guzmán, Francisco Manuel; De Salazar, Adolfo; Viñuela, Laura; Fuentes, Ana; Chueca, Natalia; The Andalusian COVID-19 Sequencing Initiative; García, FedericoEditorial
MDPI
Materia
SARS-CoV-2 Co-infection Recombination Surveillance Epidemiology
Fecha
2023-01-26Referencia bibliográfica
Perez-Florido, J... [et al.]. Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia. Int. J. Mol. Sci. 2023, 24, 2419. [https://doi.org/10.3390/ijms24032419]
Patrocinador
Ministry of Science and Innovation, Spain (MICINN) Spanish Government PID2020-117979RB-I00; Instituto de Salud Carlos III; European Commission IMP/00019; Junta de Andalucia COVID-0012-2020 PS-2020-342 IE19_259 FPSResumen
Recombination is an evolutionary strategy to quickly acquire new viral properties inherited
from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the
Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number
of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole
genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme.
Sample sources included the main hospitals in the Andalusia region. In addition to the increase of
co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron
recombinant variants with two break points have been detected. Our observations document an
epidemiological scenario in which co-infection and recombination are detected more frequently.
Finally, we describe a family case in which co-infection is followed by the detection of a recombinant
made from the two co-infecting variants. This increased number of recombinants raises the risk of
emergence of recombinant variants with increased transmissibility and pathogenicity.