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Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia
dc.contributor.author | Pérez Florido, Javier | |
dc.contributor.author | Ortuño Guzmán, Francisco Manuel | |
dc.contributor.author | De Salazar, Adolfo | |
dc.contributor.author | Viñuela, Laura | |
dc.contributor.author | Fuentes, Ana | |
dc.contributor.author | Chueca, Natalia | |
dc.contributor.author | The Andalusian COVID-19 Sequencing Initiative | |
dc.contributor.author | García, Federico | |
dc.date.accessioned | 2023-03-28T08:02:41Z | |
dc.date.available | 2023-03-28T08:02:41Z | |
dc.date.issued | 2023-01-26 | |
dc.identifier.citation | Perez-Florido, J... [et al.]. Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia. Int. J. Mol. Sci. 2023, 24, 2419. [https://doi.org/10.3390/ijms24032419] | es_ES |
dc.identifier.uri | https://hdl.handle.net/10481/80891 | |
dc.description.abstract | Recombination is an evolutionary strategy to quickly acquire new viral properties inherited from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme. Sample sources included the main hospitals in the Andalusia region. In addition to the increase of co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron recombinant variants with two break points have been detected. Our observations document an epidemiological scenario in which co-infection and recombination are detected more frequently. Finally, we describe a family case in which co-infection is followed by the detection of a recombinant made from the two co-infecting variants. This increased number of recombinants raises the risk of emergence of recombinant variants with increased transmissibility and pathogenicity. | es_ES |
dc.description.sponsorship | Ministry of Science and Innovation, Spain (MICINN) Spanish Government PID2020-117979RB-I00 | es_ES |
dc.description.sponsorship | Instituto de Salud Carlos III | es_ES |
dc.description.sponsorship | European Commission IMP/00019 | es_ES |
dc.description.sponsorship | Junta de Andalucia COVID-0012-2020 PS-2020-342 IE19_259 FPS | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | SARS-CoV-2 | es_ES |
dc.subject | Co-infection | es_ES |
dc.subject | Recombination | es_ES |
dc.subject | Surveillance | es_ES |
dc.subject | Epidemiology | es_ES |
dc.title | Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.doi | 10.3390/ijms24032419 | |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |