@misc{10481/80891,
year = {2023},
month = {1},
url = {https://hdl.handle.net/10481/80891},
abstract = {Recombination is an evolutionary strategy to quickly acquire new viral properties inherited
from the parental lineages. The systematic survey of the SARS-CoV-2 genome sequences of the
Andalusian genomic surveillance strategy has allowed the detection of an unexpectedly high number
of co-infections, which constitute the ideal scenario for the emergence of new recombinants. Whole
genome sequence of SARS-CoV-2 has been carried out as part of the genomic surveillance programme.
Sample sources included the main hospitals in the Andalusia region. In addition to the increase of
co-infections and known recombinants, three novel SARS-CoV-2 delta-omicron and omicron-omicron
recombinant variants with two break points have been detected. Our observations document an
epidemiological scenario in which co-infection and recombination are detected more frequently.
Finally, we describe a family case in which co-infection is followed by the detection of a recombinant
made from the two co-infecting variants. This increased number of recombinants raises the risk of
emergence of recombinant variants with increased transmissibility and pathogenicity.},
organization = {Ministry of Science and Innovation, Spain (MICINN)
Spanish Government	PID2020-117979RB-I00},
organization = {Instituto de Salud Carlos III},
organization = {European Commission	IMP/00019},
organization = {Junta de Andalucia	COVID-0012-2020
PS-2020-342
IE19_259 FPS},
publisher = {MDPI},
keywords = {SARS-CoV-2},
keywords = {Co-infection},
keywords = {Recombination},
keywords = {Surveillance},
keywords = {Epidemiology},
title = {Detection of High Level of Co-Infection and the Emergence of Novel SARS CoV-2 Delta-Omicron and Omicron-Omicron Recombinants in the Epidemiological Surveillance of Andalusia},
doi = {10.3390/ijms24032419},
author = {Pérez Florido, Javier and Ortuño Guzmán, Francisco Manuel and De Salazar, Adolfo and Viñuela, Laura and Fuentes, Ana and Chueca, Natalia and The Andalusian COVID-19 Sequencing Initiative and García, Federico},
}