Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults
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AuthorXu, Huiwen; Jurado Fasoli, Lucas; Ortiz Álvarez, Lourdes; Osuna Prieto, Francisco Javier; Plaza Díaz, Julio; Gil Hernández, Ángel; Ruiz Ruiz, Jonatan; Martínez Téllez, Borja Manuel
Gut microbiotaInflammationIntestinal alkaline phosphataseMicrobiomePUFAs
Xu, H... [et al.]. Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults. Nutrients 2022, 14, 4991. [https://doi.org/10.3390/nu14234991]
SponsorshipSpanish Ministry of Economy and Competitiveness via Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III PI13/01393 PTA 12264-I; Retos de la Sociedad DEP2016-79512-R; European Commission Spanish Government FPU16/05159 FPU16/02828 FPU17/01523 FPU19/01609; Fundacion Iberoamericana de Nutricion (FINUT); University of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES); AstraZeneca; Junta de Andalucia Consejeria de Conocimiento, Investigacion y Universidades (ERDF) SOMM17/6107/UGR; China Scholarship Council 201707060012; Fundacion Alfonso Martin Escudero; Ministerio de Universidades y la Union Europea -NextGenerationEU RR_C_2021_04; European Commission through the "European funds for regional development" (EFRE) regional Ministry of Economy, Science and Digitalization of Saxony-Anhalt as part of the Autonomy in old Age "(AiA) research group for "LiLife" Project ZS/2018/11/95324
Pre-clinical studies suggest that circulating oxylipins, i.e., the oxidation products of polyunsaturated fatty acids (PUFAs), modulate gut microbiota composition in mice, but there is no information available in humans. Therefore, this study aimed to investigate the relationship between omega-3 and omega-6 derived oxylipins plasma levels and fecal microbiota composition in a cohort of young adults. 80 young adults (74% women; 21.9 +/- 2.2 years old) were included in this cross-sectional study. Plasma levels of oxylipins were measured using liquid chromatography-tandem mass spectrometry. Fecal microbiota composition was analyzed by V3-V4 16S rRNA gene sequencing. We observed that plasma levels of omega-3 derived oxylipins were positively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho >= 0.415, p <= 0.009) and negatively associated with the relative abundance of Sutterella genus (Proteobacteria phylum; rho >= -0.270, p <= 0.041), respectively. Moreover, plasma levels of omega-6 derived oxylipins were negatively associated with the relative abundance of Acidaminococcus and Phascolarctobacterium genera (Firmicutes phylum; all rho >= -0.263, p <= 0.024), as well as Sutterella, Succinivibrio, and Gemmiger genera (Proteobacteria phylum; all rho >= -0.263, p <= 0.024). Lastly, the ratio between omega-6 and omega-3 oxylipins plasma levels was negatively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho = -0.334, p = 0.004) and Butyricimonas genus (Bacteroidetes phylum; rho = -0.292, p = 0.014). In conclusion, our results show that the plasma levels of omega-3 and omega-6 derived oxylipins are associated with the relative abundance of specific fecal bacteria genera.