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dc.contributor.authorXu, Huiwen 
dc.contributor.authorJurado Fasoli, Lucas 
dc.contributor.authorOrtiz Álvarez, Lourdes 
dc.contributor.authorOsuna Prieto, Francisco Javier 
dc.contributor.authorPlaza Díaz, Julio 
dc.contributor.authorGil Hernández, Ángel 
dc.contributor.authorRuiz Ruiz, Jonatan 
dc.contributor.authorMartínez Téllez, Borja Manuel 
dc.date.accessioned2023-01-17T13:32:05Z
dc.date.available2023-01-17T13:32:05Z
dc.date.issued2022-11-24
dc.identifier.citationXu, H... [et al.]. Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults. Nutrients 2022, 14, 4991. [https://doi.org/10.3390/nu14234991]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/79065
dc.description.abstractPre-clinical studies suggest that circulating oxylipins, i.e., the oxidation products of polyunsaturated fatty acids (PUFAs), modulate gut microbiota composition in mice, but there is no information available in humans. Therefore, this study aimed to investigate the relationship between omega-3 and omega-6 derived oxylipins plasma levels and fecal microbiota composition in a cohort of young adults. 80 young adults (74% women; 21.9 +/- 2.2 years old) were included in this cross-sectional study. Plasma levels of oxylipins were measured using liquid chromatography-tandem mass spectrometry. Fecal microbiota composition was analyzed by V3-V4 16S rRNA gene sequencing. We observed that plasma levels of omega-3 derived oxylipins were positively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho >= 0.415, p <= 0.009) and negatively associated with the relative abundance of Sutterella genus (Proteobacteria phylum; rho >= -0.270, p <= 0.041), respectively. Moreover, plasma levels of omega-6 derived oxylipins were negatively associated with the relative abundance of Acidaminococcus and Phascolarctobacterium genera (Firmicutes phylum; all rho >= -0.263, p <= 0.024), as well as Sutterella, Succinivibrio, and Gemmiger genera (Proteobacteria phylum; all rho >= -0.263, p <= 0.024). Lastly, the ratio between omega-6 and omega-3 oxylipins plasma levels was negatively associated with the relative abundance of Clostridium cluster IV genus (Firmicutes phylum; rho = -0.334, p = 0.004) and Butyricimonas genus (Bacteroidetes phylum; rho = -0.292, p = 0.014). In conclusion, our results show that the plasma levels of omega-3 and omega-6 derived oxylipins are associated with the relative abundance of specific fecal bacteria genera.es_ES
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness via Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III PI13/01393 PTA 12264-Ies_ES
dc.description.sponsorshipRetos de la Sociedad DEP2016-79512-Res_ES
dc.description.sponsorshipEuropean Commission Spanish Government FPU16/05159 FPU16/02828 FPU17/01523 FPU19/01609es_ES
dc.description.sponsorshipFundacion Iberoamericana de Nutricion (FINUT)es_ES
dc.description.sponsorshipUniversity of Granada Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)es_ES
dc.description.sponsorshipAstraZenecaes_ES
dc.description.sponsorshipJunta de Andalucia Consejeria de Conocimiento, Investigacion y Universidades (ERDF) SOMM17/6107/UGRes_ES
dc.description.sponsorshipChina Scholarship Council 201707060012es_ES
dc.description.sponsorshipFundacion Alfonso Martin Escuderoes_ES
dc.description.sponsorshipMinisterio de Universidades y la Union Europea -NextGenerationEU RR_C_2021_04es_ES
dc.description.sponsorshipEuropean Commission through the "European funds for regional development" (EFRE) regional Ministry of Economy, Science and Digitalization of Saxony-Anhalt as part of the Autonomy in old Age "(AiA) research group for "LiLife" Project ZS/2018/11/95324es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGut microbiotaes_ES
dc.subjectInflammation es_ES
dc.subjectIntestinal alkaline phosphatasees_ES
dc.subjectMicrobiomees_ES
dc.subjectPUFAses_ES
dc.titlePlasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adultses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/nu14234991
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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