Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker
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AuthorRojas Macías, Sara; García García, Amalia; Rosales, María; Montes Andrés, Helena; Rodríguez Diéguez, Antonio
Metal-organic frameworksZincAntibacterial activity
Rojas, S... [et al.]. Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker. Nanomaterials 2022, 12, 4139. [https://doi.org/10.3390/nano12234139]
SponsorshipMCIN/AEI by the European Union NextGenerationEU/PRTR) PCI2020-111998 MCIN/AEI PID2019-104228RB-100 PGC2018-102052-B-C21 JC2019-038894-I; Junta de Andalucia B-FQM-734-UGR20 B-FQM-478-UGR20 FQM-394; Comunidad de Madrid RED2018-102471-T; European Regional Development Fund-FEDER 2014-2020-OE REACT-UE 1; SKA South Africa 897678; Madrid Community 2018-T2/IND-11407 2017-T2/IND-5149; European Union NextGenerationEU/PRTR
Metal–organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn4( 4-O)( -FA)L2] (GR-MOF-8) and [Zn4( 4-O)L2(H2O)] (GR-MOF-9) (H3L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against Staphylococcus aureus (SA) and Escherichia Coli (EC) by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of SA, with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism.