Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker Rojas Macías, Sara García García, Amalia Rosales, María Montes Andrés, Helena Rodríguez Diéguez, Antonio Metal-organic frameworks Zinc Antibacterial activity Metal–organic frameworks (MOFs) can be used as reservoirs of metal ions with relevant antibacterial effects. Here, two novel Zn-based MOFs with the formulas [Zn4( 4-O)( -FA)L2] (GR-MOF-8) and [Zn4( 4-O)L2(H2O)] (GR-MOF-9) (H3L: 5-((4-carboxyphenyl)ethynyl) in isophthalic acid and FA (formate anion) were solvothermally synthetized and fully characterized. The antibacterial activity of GR-MOF-8 and 9 was investigated against Staphylococcus aureus (SA) and Escherichia Coli (EC) by the agar diffusion method. Both bacteria are among the most relevant human and animal pathogens, causing a wide variety of infections, and are often related with the development of antimicrobial resistances. While both Zn-based materials exhibited antibacterial activity against both strains, GR-MOF-8 showed the highest inhibitory action, likely due to a more progressive Zn release under the tested experimental conditions. This is particularly evidenced in the inhibition of SA, with an increasing effect of GR-MOF-8 with time, which is of great significance to ensure the disappearance of the microorganism. 2023-01-17T12:57:21Z 2023-01-17T12:57:21Z 2022-11-23 info:eu-repo/semantics/article Rojas, S... [et al.]. Antibacterial Activity of Two Zn-MOFs Containing a Tricarboxylate Linker. Nanomaterials 2022, 12, 4139. [https://doi.org/10.3390/nano12234139] https://hdl.handle.net/10481/79062 10.3390/nano12234139 eng http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional MDPI