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dc.contributor.authorVellido Pérez, José Antonio 
dc.contributor.authorRodríguez Remacho, Carlos
dc.contributor.authorRodríguez Rodríguez, Javier
dc.contributor.authorOchando Pulido, Javier Miguel 
dc.contributor.authorBrito de la Fuente, Edmundo
dc.contributor.authorMartínez Férez, Antonio 
dc.date.accessioned2023-01-16T09:04:26Z
dc.date.available2023-01-16T09:04:26Z
dc.date.issued2019-06-15
dc.identifier.citationVellido Perez, J. A., Rodriguez Remacho, C., Rodriguez Rodriguez, J., Ochando Pulido, J. M., Brito De La Fuente, E., & Martinez-Ferez, A. (2019). Optimization of Oleogel Formulation for Curcumin Vehiculization and Lipid Oxidation Stability by Multi-response Surface Methodology. Chemical Engineering Transactions, 75, 427-432. [https://doi.org/10.3303/CET1975072]es_ES
dc.identifier.urihttps://hdl.handle.net/10481/79012
dc.description.abstractCurcumin is a natural polyphenolic compound with multiple properties such as anticancer, anti-inflammatory, antioxidant, antiviral, and cytoprotective action. It is expected that curcumin has the therapeutic potential to prevent diverse lifestyle-related diseases. However, curcumin is not readily soluble in water and presents low stability under light, heat and physiological pH conditions which, in addition, implies an extremely low level of bioavailability. On the other hand, oleogels are semisolid systems composed of a liquid phase that is physically entrapped by a structurant network, ultimately leading to the formation of a gel. The continuous phase consists of a hydrophobic liquid (e.g., an oil) where a self-assembled network (composed by the structurant) is responsible for the physical entrapment of the liquid. The structural conformation is always dependent on the type of structurant used, which will dictate the desired final application of the oleogels. In this work, the formulation of an oleogel specially designed to stabilize and transport curcumin and to protect the lipid phase –mainly composed of a fish oil concentrate– against oxidation processes has been optimized. To this end, a Box-Behnken Design was carried out to study the influence of the curcumin amount, the structurant concentration and the manufacturing temperature on the oxidation degree of the oleogelified lipid matrix and on the chemical stability of the curcumin transported by this system. The results were interpreted by using the multi-response surface methodology, obtaining the optimal oleogel formulation to minimize the lipid oxidation and maximize the content of vehiculized curcumin. The results show that the optimal oleogel formulation –for samples stored at 23 ºC– was achieved for the following values of the variables studied: [Curc.] = 0.150 wt.%, [Struc.] = 4.461 wt.% and T = 64.63 ºC. In contrast, for samples stored at 40 ºC, the optimal formulation obtained changed slightly: [Curc.] = 0.150 wt.%, [Struc.] = 7.000 wt.% and T = 62.82 ºC. Finally, results suggest that oleogels are interesting structured lipid systems to transport and protect bioactive compounds.es_ES
dc.description.sponsorshipThis work was supported by the Research Group TEP025 “Technologies for Chemical and Biochemical Processes” from the Chemical Engineering Department of the University of Granada. The Ministry of Education, Culture and Sport (MECD) is deeply grateful for supporting the grant FPU17/03005 of Mr. Vellido-Perez.es_ES
dc.language.isoenges_ES
dc.publisherAIDIC-Italian Association of Chemical Engineeringes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleOptimization of Oleogel Formulation for Curcumin Vehiculization and Lipid Oxidation Stability by Multi-Response Surface Methodologyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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