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The Arginine Catabolism-Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa
dc.contributor.author | Dhodary, Basanta | |
dc.contributor.author | Sampedro Quesada, María Inmaculada | |
dc.date.accessioned | 2022-03-23T07:42:52Z | |
dc.date.available | 2022-03-23T07:42:52Z | |
dc.date.issued | 2022-01-24 | |
dc.identifier.citation | Dhodary, B... [et al.]. The Arginine Catabolism- Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa. Microorganisms 2022, 10, 264. [https://doi.org/10.3390/microorganisms10020264] | es_ES |
dc.identifier.uri | http://hdl.handle.net/10481/73652 | |
dc.description | This research was funded, in part, by the United States Cystic Fibrosis Foundation (Hill16I0). | es_ES |
dc.description.abstract | Pseudomonas aeruginosa is a common, opportunistic bacterial pathogen among patients with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these diseases, L-ornithine, a non-proteinogenic amino acid, becomes more abundant. P. aeruginosa is chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response of P. aeruginosa towards L-ornithine. Our results show that L-ornithine serves as a chemoattractant for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved in P. aeruginosa PAO1 are PctA and PctB. It seems likely that P. aeruginosa’s chemotactic response to L-ornithine might be a common feature and thus could potentially contribute to pathogenesis processes during colonization and infection scenarios. | es_ES |
dc.description.sponsorship | United States Cystic Fibrosis Foundation Hill16I0 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Chemotaxis | es_ES |
dc.subject | L-ornithine | es_ES |
dc.subject | Pseudomonas aeruginosa | es_ES |
dc.subject | Chemoreceptor | es_ES |
dc.title | The Arginine Catabolism-Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.identifier.doi | 10.3390/microorganisms10020264 | |
dc.type.hasVersion | VoR | es_ES |