The Arginine Catabolism-Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa
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MDPI
Materia
Chemotaxis L-ornithine Pseudomonas aeruginosa Chemoreceptor
Date
2022-01-24Referencia bibliográfica
Dhodary, B... [et al.]. The Arginine Catabolism- Derived Amino Acid L-ornithine Is a Chemoattractant for Pseudomonas aeruginosa. Microorganisms 2022, 10, 264. [https://doi.org/10.3390/microorganisms10020264]
Sponsorship
United States Cystic Fibrosis Foundation Hill16I0Abstract
Pseudomonas aeruginosa is a common, opportunistic bacterial pathogen among patients
with cystic fibrosis, asthma, and chronic obstructive pulmonary disease. During the course of these
diseases, L-ornithine, a non-proteinogenic amino acid, becomes more abundant. P. aeruginosa is
chemotactic towards other proteinogenic amino acids. Here, we evaluated the chemotaxis response
of P. aeruginosa towards L-ornithine. Our results show that L-ornithine serves as a chemoattractant
for several strains of P. aeruginosa, including clinical isolates, and that the chemoreceptors involved
in P. aeruginosa PAO1 are PctA and PctB. It seems likely that P. aeruginosa’s chemotactic response
to L-ornithine might be a common feature and thus could potentially contribute to pathogenesis
processes during colonization and infection scenarios.