Muscle Satellite Cell Heterogeneity: Does Embryonic Origin Matter?
Metadatos
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Rodríguez Outeiriño, Lara; Hernández Torres, Francisco; Ramírez de Acuña, Felicitas; Matías Valiente, Lidia; Sánchez Fernández, Cristina; Franco, Diego; Aránega, Amelia EvaEditorial
Frontiers Research Foundation
Materia
Myogenic precursor cells Embryonic myogenesis Adult myogenesis Satellite cell heterogeneity Muscle regeneration
Fecha
2021-10-15Referencia bibliográfica
Rodriguez-Outeiriño L... [et al.] (2021) Muscle Satellite Cell Heterogeneity: Does Embryonic Origin Matter? Front. Cell Dev. Biol. 9:750534. doi: [10.3389/fcell.2021.750534]
Patrocinador
Spanish Government PID2019-10 7492GB-I00; FEDER ANDALUCIA (Junta de Andalucia, Spain) 06030050P1 PROY I + D + I; Spanish Government FPU17/03843Resumen
Muscle regeneration is an important homeostatic process of adult skeletal muscle
that recapitulates many aspects of embryonic myogenesis. Satellite cells (SCs) are
the main muscle stem cells responsible for skeletal muscle regeneration. SCs reside
between the myofiber basal lamina and the sarcolemma of the muscle fiber in a
quiescent state. However, in response to physiological stimuli or muscle trauma,
activated SCs transiently re-enter the cell cycle to proliferate and subsequently exit
the cell cycle to differentiate or self-renew. Recent evidence has stated that SCs
display functional heterogeneity linked to regenerative capability with an undifferentiated
subgroup that is more prone to self-renewal, as well as committed progenitor cells
ready for myogenic differentiation. Several lineage tracing studies suggest that such
SC heterogeneity could be associated with different embryonic origins. Although it has
been established that SCs are derived from the central dermomyotome, how a small
subpopulation of the SCs progeny maintain their stem cell identity while most progress
through the myogenic program to construct myofibers is not well understood. In this
review, we synthesize the works supporting the different developmental origins of SCs
as the genesis of their functional heterogeneity.