Muscle Satellite Cell Heterogeneity: Does Embryonic Origin Matter? Rodríguez Outeiriño, Lara Hernández Torres, Francisco Ramírez de Acuña, Felicitas Matías Valiente, Lidia Sánchez Fernández, Cristina Franco, Diego Aránega, Amelia Eva Myogenic precursor cells Embryonic myogenesis Adult myogenesis Satellite cell heterogeneity Muscle regeneration Funding This work was partially supported by grants PID2019-10 7492GB-I00 (Ministerio de Ciencia e Innovacion, Spain) and 06030050P1 PROY I + D + I. FEDER ANDALUCIA (Junta de Andalucia, Spain). LR-O is recipient of a FPU grant (FPU17/03843). Muscle regeneration is an important homeostatic process of adult skeletal muscle that recapitulates many aspects of embryonic myogenesis. Satellite cells (SCs) are the main muscle stem cells responsible for skeletal muscle regeneration. SCs reside between the myofiber basal lamina and the sarcolemma of the muscle fiber in a quiescent state. However, in response to physiological stimuli or muscle trauma, activated SCs transiently re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent evidence has stated that SCs display functional heterogeneity linked to regenerative capability with an undifferentiated subgroup that is more prone to self-renewal, as well as committed progenitor cells ready for myogenic differentiation. Several lineage tracing studies suggest that such SC heterogeneity could be associated with different embryonic origins. Although it has been established that SCs are derived from the central dermomyotome, how a small subpopulation of the SCs progeny maintain their stem cell identity while most progress through the myogenic program to construct myofibers is not well understood. In this review, we synthesize the works supporting the different developmental origins of SCs as the genesis of their functional heterogeneity. 2021-12-01T11:40:53Z 2021-12-01T11:40:53Z 2021-10-15 info:eu-repo/semantics/article Rodriguez-Outeiriño L... [et al.] (2021) Muscle Satellite Cell Heterogeneity: Does Embryonic Origin Matter? Front. Cell Dev. Biol. 9:750534. doi: [10.3389/fcell.2021.750534] http://hdl.handle.net/10481/71844 10.3389/fcell.2021.750534 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Frontiers Research Foundation