Basic Quality Controls Used in Skin Tissue Engineering
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AuthorLinares González, Laura; Ródenas Herranz, Teresa; Campos Sánchez, Fernando; Ruiz Villaverde, Ricardo; Carriel Araya, Víctor
Skin tissue engineeringQuality controlHistological techniquesBiochemical methodsBiomechanical evaluation
Linares-Gonzalez, L... [et al.]. Basic Quality Controls Used in Skin Tissue Engineering. Life 2021, 11, 1033. [https://doi.org/10.3390/life11101033]
SponsorshipPE-0395-2019 from Consejería de Salud y Familias, Junta de Andalucía, Spain
Reconstruction of skin defects is often a challenging effort due to the currently limited reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to replace or repair diseased or damaged tissues from the patient’s own cells. A substantial number of tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo showing promising results in the preclinical stage. However, only a few constructs have been used in the clinic. The lack of standardization in evaluation methods employed may in part be responsible for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are proposed.