Basic Quality Controls Used in Skin Tissue Engineering Linares González, Laura Ródenas Herranz, Teresa Campos Sánchez, Fernando Ruiz Villaverde, Ricardo Carriel Araya, Víctor Skin tissue engineering Quality control Histological techniques Biochemical methods Biomechanical evaluation Supported by PE-0395-2019 from Consejería de Salud y Familias, Junta de Andalucía, Spain. Reconstruction of skin defects is often a challenging effort due to the currently limited reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to replace or repair diseased or damaged tissues from the patient’s own cells. A substantial number of tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo showing promising results in the preclinical stage. However, only a few constructs have been used in the clinic. The lack of standardization in evaluation methods employed may in part be responsible for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are proposed. 2021-11-23T12:02:21Z 2021-11-23T12:02:21Z 2021-09-30 info:eu-repo/semantics/article Linares-Gonzalez, L... [et al.]. Basic Quality Controls Used in Skin Tissue Engineering. Life 2021, 11, 1033. [https://doi.org/10.3390/life11101033] http://hdl.handle.net/10481/71694 10.3390/life11101033 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI