@misc{10481/71694, year = {2021}, month = {9}, url = {http://hdl.handle.net/10481/71694}, abstract = {Reconstruction of skin defects is often a challenging effort due to the currently limited reconstructive options. In this sense, tissue engineering has emerged as a possible alternative to replace or repair diseased or damaged tissues from the patient’s own cells. A substantial number of tissue-engineered skin substitutes (TESSs) have been conceived and evaluated in vitro and in vivo showing promising results in the preclinical stage. However, only a few constructs have been used in the clinic. The lack of standardization in evaluation methods employed may in part be responsible for this discrepancy. This review covers the most well-known and up-to-date methods for evaluating the optimization of new TESSs and orientative guidelines for the evaluation of TESSs are proposed.}, organization = {PE-0395-2019 from Consejería de Salud y Familias, Junta de Andalucía, Spain}, publisher = {MDPI}, keywords = {Skin tissue engineering}, keywords = {Quality control}, keywords = {Histological techniques}, keywords = {Biochemical methods}, keywords = {Biomechanical evaluation}, title = {Basic Quality Controls Used in Skin Tissue Engineering}, doi = {10.3390/life11101033}, author = {Linares González, Laura and Ródenas Herranz, Teresa and Campos Sánchez, Fernando and Ruiz Villaverde, Ricardo and Carriel Araya, Víctor}, }