Nutrition and cellular senescence in obesity-related disorders
Metadatos
Mostrar el registro completo del ítemEditorial
Elsevier
Materia
Aging Diet Inflammation Microbiota obesity Senescence
Fecha
2021-09-11Referencia bibliográfica
Teresa Rubio-Tomás... [et al.]. Nutrition and cellular senescence in obesity-related disorders, The Journal of Nutritional Biochemistry, Volume 99, 2022, 108861, ISSN 0955-2863, [https://doi.org/10.1016/j.jnutbio.2021.108861]
Patrocinador
UGR Plan Propio de Investigación 2016; Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada; “Fundación Ramón Are- ces”, Madrid, Spain.; Universidad de Granada / CBUAResumen
Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western
diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous
system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated
secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The
present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation
and senescence.