Nutrition and cellular senescence in obesity-related disorders Rubio Tomás, Teresa Rueda Robles, Ascensión Plaza Díaz, Julio Álvarez Mercado, Ana Isabel Aging Diet Inflammation Microbiota obesity Senescence Julio Plaza-Diaz is part of the “UGR Plan Propio de Investigación 2016 and the “Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada”. Julio Plaza-Diaz is sup- ported by a grant awarded to postdoctoral researchers at foreign universities and research centers from the “Fundación Ramón Are- ces”, Madrid, Spain. Funding for open access charge: Universidad de Granada / CBUA. Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation and senescence. 2021-11-15T09:08:17Z 2021-11-15T09:08:17Z 2021-09-11 journal article Teresa Rubio-Tomás... [et al.]. Nutrition and cellular senescence in obesity-related disorders, The Journal of Nutritional Biochemistry, Volume 99, 2022, 108861, ISSN 0955-2863, [https://doi.org/10.1016/j.jnutbio.2021.108861] http://hdl.handle.net/10481/71511 10.1016/j.jnutbio.2021.108861 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Elsevier