Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties
MetadatosMostrar el registro completo del ítem
AutorVezza, Teresa; Garrido Mesa, José; Díez Echave, Patricia; Hidalgo García, Laura; Ruiz Malagón, Antonio Jesús; García García, Federico; Sánchez Santos, Manuel; Toral, Marta; Romero Pérez, Miguel; Duarte Pérez, Juan Manuel; Guillamón, Enrique; Baños Arjona, Alberto; Morón Romero, María Rocío; Gálvez Peralta, Julio Juan; Rodríguez Nogales, Alba; Rodríguez Cabezas, María Elena
CytokinesDysbiosisGlucose metabolismLipid metabolismMicrobiotaObesityOrganosulfur compound
Vezza, T... [et al.]. Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients 2021, 13, 2595. [https://doi.org/10.3390/nu13082595]
PatrocinadorFEDER-INNTERCONECTA-CDTI program (CDTI, Centre for the Development of Industrial Technology) ITC-20181038; Junta de Andalucia CTS 164; Instituto de Salud Carlos III European Commission PI19/01058 European Commission Instituto de Salud Carlos III; European Commission
Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesityassociated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ß, Il-6, Tnf-a, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-a, Ppar-g, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.