@misc{10481/70812,
year = {2021},
month = {7},
url = {http://hdl.handle.net/10481/70812},
abstract = {Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from
Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects
in different experimental models. In this sense, our aim was to evaluate its effect on an experimental
model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota.
Methods and results: Mice were fed a high-fat diet and orally treated with different doses of
PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the
plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesityassociated
systemic inflammation, reducing the immune cell infiltration and, thus, the expression
of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ß, Il-6, Tnf-a, Mcp-1, Jnk-1, Jnk-2,
Leptin, Leptin R, Adiponectin, Ampk, Ppar-a, Ppar-g, Glut-4 and Tlr-4) and improving the expression of
different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally,
these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat
diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of
metabolic syndrome.},
organization = {FEDER-INNTERCONECTA-CDTI program (CDTI, Centre for the Development of Industrial Technology)	ITC-20181038},
organization = {Junta de Andalucia	CTS 164},
organization = {Instituto de Salud Carlos III
European Commission	PI19/01058	
European Commission		
Instituto de Salud Carlos III},
organization = {European Commission},
publisher = {MDPI},
keywords = {Cytokines},
keywords = {Dysbiosis},
keywords = {Glucose metabolism},
keywords = {Lipid metabolism},
keywords = {Microbiota},
keywords = {Obesity},
keywords = {Organosulfur compound},
title = {Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties},
doi = {10.3390/nu13082595},
author = {Vezza, Teresa and Garrido Mesa, José and Díez Echave, Patricia and Hidalgo García, Laura and Ruiz Malagón, Antonio Jesús and García García, Federico and Sánchez Santos, Manuel and Toral, Marta and Romero Pérez, Miguel and Duarte Pérez, Juan Manuel and Guillamón, Enrique and Baños Arjona, Alberto and Morón Romero, María Rocío and Gálvez Peralta, Julio Juan and Rodríguez Nogales, Alba and Rodríguez Cabezas, María Elena},
}