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dc.contributor.authorVezza, Teresa
dc.contributor.authorGarrido Mesa, José
dc.contributor.authorDíez Echave, Patricia 
dc.contributor.authorHidalgo García, Laura 
dc.contributor.authorRuiz Malagón, Antonio Jesús 
dc.contributor.authorGarcía García, Federico
dc.contributor.authorSánchez Santos, Manuel 
dc.contributor.authorToral, Marta
dc.contributor.authorRomero Pérez, Miguel 
dc.contributor.authorDuarte Pérez, Juan Manuel 
dc.contributor.authorGuillamón, Enrique
dc.contributor.authorBaños Arjona, Alberto
dc.contributor.authorMorón Romero, María Rocío 
dc.contributor.authorGálvez Peralta, Julio Juan 
dc.contributor.authorRodríguez Nogales, Alba 
dc.contributor.authorRodríguez Cabezas, María Elena
dc.identifier.citationVezza, T... [et al.]. Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties. Nutrients 2021, 13, 2595. []es_ES
dc.descriptionThis research was funded by the FEDER-INNTERCONECTA-CDTI program (CDTI, Centre for the Development of Industrial Technology; NATURPICK Project ITC-20181038), by the Junta de Andalucia (CTS 164) and by Instituto de Salud Carlos III (PI19/01058) with funds from the European Union. T.V. is a postdoctoral fellow from Instituto de Investigacion Biosanitaria de Granada; A.J.R.-M. and L.H.-G. are predoctoral fellows from University of Granada ("Programa de Doctorado: Medicina Clinica y Salud Publica"); P.D.-E. is a postdoctoral fellow from University of Granada. The CIBER-EHD and CIBERCV are funded by the Instituto de Salud Carlos III.es_ES
dc.description.abstractBackground: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on an experimental model of obesity, focusing on inflammatory and metabolic markers and the gut microbiota. Methods and results: Mice were fed a high-fat diet and orally treated with different doses of PTSO (0.1, 0.5 and 1 mg/kg/day) for 5 weeks. PTSO lessened the weight gain and improved the plasma markers associated with glucose and lipid metabolisms. PTSO also attenuated obesityassociated systemic inflammation, reducing the immune cell infiltration and, thus, the expression of pro-inflammatory cytokines in adipose and hepatic tissues (Il-1ß, Il-6, Tnf-a, Mcp-1, Jnk-1, Jnk-2, Leptin, Leptin R, Adiponectin, Ampk, Ppar-a, Ppar-g, Glut-4 and Tlr-4) and improving the expression of different key elements for gut barrier integrity (Muc-2, Muc-3, Occludin, Zo-1 and Tff-3). Additionally, these effects were connected to a regulation of the gut microbiome, which was altered by the high-fat diet. Conclusion: Allium-derived PTSO can be considered a potential new tool for the treatment of metabolic syndrome.es_ES
dc.description.sponsorshipFEDER-INNTERCONECTA-CDTI program (CDTI, Centre for the Development of Industrial Technology) ITC-20181038es_ES
dc.description.sponsorshipJunta de Andalucia CTS 164es_ES
dc.description.sponsorshipInstituto de Salud Carlos III European Commission PI19/01058 European Commission Instituto de Salud Carlos IIIes_ES
dc.description.sponsorshipEuropean Commissiones_ES
dc.rightsAtribución 3.0 España*
dc.subjectCytokines es_ES
dc.subjectGlucose metabolismes_ES
dc.subjectLipid metabolismes_ES
dc.subjectObesity es_ES
dc.subjectOrganosulfur compoundes_ES
dc.titleAllium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Propertieses_ES

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Atribución 3.0 España
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