Neural signatures of predictive language processing in parkinson’s disease with and without mild cognitive impairment
Metadatos
Mostrar el registro completo del ítemFecha
2021Referencia bibliográfica
bioRxiv 2020.11.23.392647; [doi: https://doi.org/10.1101/2020.11.23.392647]
Patrocinador
Fundació la Marató de TV3 2014/U/477 and 20142910; Center for Biomedical Research and Neurodegenerative Resources (CIBERNED); FPU15/05554 (FPU "Ayudas para la Formación de Profesorado Universitario") of the Spanish Ministry of Education, Culture and Sport; PERIS (expedient number: SLT008/18/00088) of Generalitat de Catalunya; Río Hortega CM17/00209 of Instituto de Salud Carlos III (ISCIII) (Spain); FIS PI18/01717. HB -K; Río Hortega CM15/00071 of Instituto de Salud Carlos III (ISCIII) (Spain)Resumen
Cognitive deficits are common in Parkinson’s disease (PD), with some PD patients meeting criteria
for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is
preserved in PD. This ability is nowadays deemed crucial in achieving fast and efficient
comprehension, and it may be negatively impacted by cognitive deterioration. To fill this gap of
knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic
prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this
end, participants read sentence contexts that were predictive or not about a sentence-final word.
The final word appeared after 1 second, matching or mismatching the prediction. The introduction
of the interval allowed to capture neural responses both before and after sentence-final words,
reflecting semantic anticipation and processing. PD patients with normal cognition (N = 58)
showed ERP responses comparable to those of matched controls. Specifically, in predictive
contexts, a slow negative potential developed prior to sentence-final words, reflecting semantic
anticipation. Later, expected words elicited reduced N400 responses (compared to unexpected
words), indicating facilitated semantic processing. Besides, PD patients with MCI (N = 20) showed
a prolongation of the N400 congruency effect (compared to matched PD patients without MCI),
indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency
scores correlated with prolonged N400 congruency effects and with reduced pre-word differences
in all PD patients (N = 78). This relevantly points to a role of deficits in temporal-dependent
mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and
semantic processing during sentence comprehension.