@misc{10481/70533,
year = {2021},
url = {http://hdl.handle.net/10481/70533},
abstract = {Cognitive deficits are common in Parkinson’s disease (PD), with some PD patients meeting criteria 
for mild cognitive impairment (MCI). An unaddressed question is whether linguistic prediction is 
preserved  in  PD.  This  ability  is  nowadays  deemed  crucial  in  achieving  fast  and  efficient 
comprehension, and it may be negatively impacted by cognitive deterioration. To fill this gap of 
knowledge, we used event-related potentials (ERPs) to evaluate mechanisms of linguistic 
prediction in a sample of PD patients (on dopamine compensation) with and without MCI. To this 
end, participants read sentence contexts that were predictive or not about a sentence-final word. 
The final word appeared after 1 second, matching or mismatching the prediction. The introduction 
of  the  interval  allowed  to  capture  neural  responses  both  before  and  after  sentence-final  words, 
reflecting  semantic  anticipation  and  processing.  PD  patients  with  normal  cognition  (N  =  58) 
showed  ERP  responses  comparable  to  those  of  matched  controls.  Specifically,  in  predictive 
contexts,  a  slow  negative  potential  developed  prior  to  sentence-final  words,  reflecting  semantic 
anticipation.  Later,  expected  words  elicited  reduced  N400  responses  (compared  to  unexpected 
words), indicating facilitated semantic processing. Besides, PD patients with MCI (N = 20) showed 
a prolongation of the N400 congruency effect (compared to matched PD patients without MCI), 
indicating that further cognitive decline impacts semantic processing. Finally, lower verbal fluency 
scores correlated with prolonged N400 congruency effects and with reduced pre-word differences 
in  all  PD  patients  (N  =  78).  This  relevantly  points  to  a  role  of  deficits  in  temporal-dependent 
mechanisms in PD, besides prototypical frontal dysfunction, in altered semantic anticipation and 
semantic processing during sentence comprehension.},
organization = {Fundació la Marató de TV3 2014/U/477 and 20142910},
organization = {Center for Biomedical Research and Neurodegenerative Resources (CIBERNED)},
organization = {FPU15/05554 (FPU "Ayudas para la Formación de Profesorado Universitario") of the Spanish Ministry of Education, Culture and Sport},
organization = {PERIS (expedient number: SLT008/18/00088) of Generalitat de Catalunya},
organization = {Río Hortega CM17/00209 of Instituto de Salud Carlos III (ISCIII) (Spain)},
organization = {FIS PI18/01717. HB -K},
organization = {Río Hortega CM15/00071 of Instituto de Salud Carlos III (ISCIII) (Spain)},
title = {Neural signatures of predictive language processing in  parkinson’s disease with and without mild cognitive impairment},
doi = {10.1101/2020.11.23.392647},
author = {León-Cabrera, Patricia and Morís Fernández, Joaquín},
}