The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology
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AuteurQuiñones Vico, María Isabel; Sanabria de la Torre, Raquel; Sánchez Diaz, Manuel; Sierra Sánchez, Álvaro; Montero Vilchez, Trinidad; Fernández González, Ana; Arias Santiago, Salvador Antonio
Frontiers Research Foundation
Exosomes-based therapyImmunomodulationMesenchymal stem cell-derived exosomesRegenerative medicineSkin autoimmune diseasesSkin wound healing
Quiñones-Vico MI, Sanabria-de la Torre R, Sánchez-Díaz M, Sierra-Sánchez Á, Montero-Vílchez T, Fernández-González A and Arias-Santiago S (2021) The Role of Exosomes Derived From Mesenchymal Stromal Cells in Dermatology. Front. Cell Dev. Biol. 9:647012. doi: [10.3389/fcell.2021.647012]
PatrocinadorCarlos III Health Institute of Spain [European Regional Development Fund "A way to make Europe"] PI13/02576 PI17/02083; Carlos III Health Institute of Spain [Andalusian Regional Government Finance] PI13/02576 PI17/02083 SAS PI-0458-2016; Spanish Ministry of Science, Innovation and Universities BOE 22/10/2019
The skin is the largest organ of the human body and its main functions include providing protection from external harmful agents, regulating body temperature, and homeostatic maintenance. Skin injuries can damage this important barrier and its functions so research focuses on approaches to accelerate wound healing and treat inflammatory skin diseases. Due to their regenerative and immunomodulatory properties, mesenchymal stromal cells (MSCs) have been reported to play a significant role in skin repair and regeneration. However, it seems that the secretome of these cells and exosomes in particular may be responsible for their functions in skin regeneration and the immunomodulation field. The present review aims to gather the available information about the role of MSC-derived exosomes for both in vitro and in vivo models of different skin conditions and to highlight the need for further research in order to overcome any limitations for clinical translation.