Circadian Genes as Therapeutic Targets in Pancreatic Cancer
MetadataShow full item record
AuthorGarcía Costela, María; Escudero Feliú, Julia; Puentes Pardo, José David; Moreno San Juan, Sara; Morales Santana, Sonia; Ríos Arrabal, Sandra; Carazo Gallego, Ángel; León López, Josefa
Frontiers Research Foundation
Pancreatic cancerCircadian clockChemotherapyMetabolismPrecision medicine
García-Costela M, Escudero-Feliú J, Puentes-Pardo JD, San Juán SM, Morales-Santana S, Ríos-Arrabal S, Carazo Á and León J (2020) Circadian Genes as Therapeutic Targets in Pancreatic Cancer. Front. Endocrinol. 11:638. doi: [10.3389/fendo.2020.00638]
SponsorshipNicolás Monardes Program from the Andalusian Health Service (C-0033-2015); Instituto de Salud Carlos III-FEDER (PI18/01947)
Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.