Circadian Genes as Therapeutic Targets in Pancreatic Cancer García Costela, María Escudero Feliú, Julia Puentes Pardo, José David Moreno San Juan, Sara Morales Santana, Sonia Ríos Arrabal, Sandra Carazo Gallego, Ángel León López, Josefa Pancreatic cancer Circadian clock Chemotherapy Metabolism Precision medicine JL was supported by the Nicolás Monardes Program from the Andalusian Health Service (C-0033-2015). This work was supported by a research grant from the Instituto de Salud Carlos III-FEDER (PI18/01947). Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports. 2021-05-17T07:57:20Z 2021-05-17T07:57:20Z 2020-09-11 info:eu-repo/semantics/article García-Costela M, Escudero-Feliú J, Puentes-Pardo JD, San Juán SM, Morales-Santana S, Ríos-Arrabal S, Carazo Á and León J (2020) Circadian Genes as Therapeutic Targets in Pancreatic Cancer. Front. Endocrinol. 11:638. doi: [10.3389/fendo.2020.00638] http://hdl.handle.net/10481/68537 10.3389/fendo.2020.00638 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Frontiers Research Foundation