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dc.contributor.authorGarcía Costela, María
dc.contributor.authorEscudero Feliú, Julia
dc.contributor.authorPuentes Pardo, José David 
dc.contributor.authorMoreno San Juan, Sara
dc.contributor.authorMorales Santana, Sonia
dc.contributor.authorRíos Arrabal, Sandra
dc.contributor.authorCarazo Gallego, Ángel
dc.contributor.authorLeón López, Josefa
dc.date.accessioned2021-05-17T07:57:20Z
dc.date.available2021-05-17T07:57:20Z
dc.date.issued2020-09-11
dc.identifier.citationGarcía-Costela M, Escudero-Feliú J, Puentes-Pardo JD, San Juán SM, Morales-Santana S, Ríos-Arrabal S, Carazo Á and León J (2020) Circadian Genes as Therapeutic Targets in Pancreatic Cancer. Front. Endocrinol. 11:638. doi: [10.3389/fendo.2020.00638]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/68537
dc.descriptionJL was supported by the Nicolás Monardes Program from the Andalusian Health Service (C-0033-2015). This work was supported by a research grant from the Instituto de Salud Carlos III-FEDER (PI18/01947).es_ES
dc.description.abstractPancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.es_ES
dc.description.sponsorshipNicolás Monardes Program from the Andalusian Health Service (C-0033-2015)es_ES
dc.description.sponsorshipInstituto de Salud Carlos III-FEDER (PI18/01947)es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectPancreatic canceres_ES
dc.subjectCircadian clockes_ES
dc.subjectChemotherapyes_ES
dc.subjectMetabolism es_ES
dc.subjectPrecision medicinees_ES
dc.titleCircadian Genes as Therapeutic Targets in Pancreatic Canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3389/fendo.2020.00638
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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