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dc.contributor.authorÁlvarez Cienfuegos Rodríguez, Luis 
dc.date.accessioned2021-04-06T07:44:51Z
dc.date.available2021-04-06T07:44:51Z
dc.date.issued2019
dc.identifier.citationCryst. Growth Des. 2019, 19, 4229−4233es_ES
dc.identifier.urihttp://hdl.handle.net/10481/67798
dc.description.abstractLysozyme crystals grown in Fmoc-CF (Cys-Phe) hydro-gels, unlike those grown in agarose, give rise to compo-site crystals that have an enhanced resistance against degradation caused by an intense exposure to X-ray irradiation. Fmoc-CF dipeptide shows a clear protection of the most sensitive groups (disulfide bonds and methi-onines) of the protein. The protection mediated by cys-teine is exerted only in its gel state since cysteine in solution has an adverse effect. Probably the reactive thiols groups of cysteine being locked within the rigid peptide fibers minimize cross-reactions with the proteins favoring the formation of protein crystals. Once located inside the protein crystal the long peptide fibers are able to protect the protein against radiation damage.es_ES
dc.description.sponsorshipProjects BIO2016-74875-P (JAG) and FIS2017-85954-R (LAC) (Ministerio de Economía, Industria y Competitivid-ad, MINECO, and Agencia Estatal de Investigación, AEI, Spain, co-funded by Fondo Europeo de Desarrollo Region-al, FEDER, European Union) and by Junta de Andalucía (Spain) projects P12-FQM-2721 and P12-FQM-790.es_ES
dc.language.isoenges_ES
dc.publisherACSes_ES
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleEnhanced Stability Against Radiation Damage of Lysozyme Crys-tals Grown in Fmoc-CF Hydrogelses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1021/acs.cgd.9b00131
dc.type.hasVersioninfo:eu-repo/semantics/draftes_ES


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