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dc.contributor.authorMartínez Aguilar, Rocío
dc.contributor.authorRomero Pinedo, Salvador
dc.contributor.authorRuiz Magaña, María José
dc.contributor.authorGarcía Olivares, Enrique Fernando 
dc.contributor.authorRuiz Ruiz, María Carmen 
dc.contributor.authorAbadía Molina, Ana Clara 
dc.date.accessioned2021-02-18T09:35:12Z
dc.date.available2021-02-18T09:35:12Z
dc.date.issued2020-12-07
dc.identifier.citationMartínez-Aguilar, R., Romero-Pinedo, S., Ruiz-Magaña, M. J., Olivares, E. G., Ruiz-Ruiz, C., & Abadía-Molina, A. C. (2020). Menstrual blood-derived stromal cells modulate functional properties of mouse and human macrophages. Scientific reports, 10(1), 1-14. [| https://doi.org/10.1038/s41598-020-78423-x]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/66648
dc.description.abstractMenstrual blood-derived stromal cells (MenSCs) are emerging as a strong candidate for cell-based therapies due to their immunomodulatory properties. However, their direct impact on innate immune populations remains elusive. Since macrophages play a key role in the onset and development of inflammation, understanding MenSCs implication in the functional properties of these cells is required to refine their clinical effects during the treatment of inflammatory disorders. In this study, we assessed the effects that MenSCs had on the recruitment of macrophages and other innate immune cells in two mouse models of acute inflammation, a thioglycollate (TGC)-elicited peritonitis model and a monobacterial sepsis model. We found that, in the TGC model, MenSCs injection reduced the percentage of macrophages recruited to the peritoneum and promoted the generation of peritoneal immune cell aggregates. In the sepsis model, MenSCs exacerbated infection by diminishing the recruitment of macrophages and neutrophils to the site of infection and inducing defective bacterial clearance. Additional in vitro studies confirmed that co-culture with MenSCs impaired macrophage bactericidal properties, affecting bacterial killing and the production of reactive oxygen intermediates. Our findings suggest that MenSCs modulate the macrophage population and that this modulation must be taken into consideration when it comes to future clinical applications.es_ES
dc.description.sponsorshipPlan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016, ISCIII-Subdirección General de Evaluación y Fomento de la Investigación, Ministerio de Economía y Competitividad, Spain PI16/01642 PI10/01096es_ES
dc.description.sponsorshipEuropean Union (EU)es_ES
dc.description.sponsorshipCatedra de Investigación Antonio Chamorro-Alejandro Otero, Universidad de Granada CACH2017-1es_ES
dc.language.isoenges_ES
dc.publisherNature Researches_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.titleMenstrual blood‑derived stromal cells modulate functional properties of mouse and human macrophageses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.1038/s41598-020-78423-x
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España