The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study
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AuthorNieto Ruiz, Ana María; Diéguez Castillo, Estefanía; Sepúlveda Valbuena, Natalia; Herrmann, Florian; Cerdó, Tomás; López Torrecillas, Francisca; Pérez García, Miguel; Miranda León, María Teresa; Catena Martínez, Andrés; García Santos, José Antonio; García Bermúdez, María Mercedes; Campoy Folgoso, Cristina
Infant formulaMilk fat globule membraneLong chain polyunsaturated fatty acidsBioactive compoundsChildren behaviorBreastfeeding
Nieto-Ruiz, A., Diéguez, E., Sepúlveda-Valbuena, N., Herrmann, F., Cerdó, T., López-Torrecillas, F., ... & Campoy, C. (2020). The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study. Nutrients, 12(12), 3825. [doi:10.3390/nu12123825]
SponsorshipOrdesa Laboratories; S.L. Contract University of Granada General Foundation 3349; SMARTFOODS (CIEN) Contract University of Granada General Foundation 4003; Spanish Ministry of Economy, Industry and Competitiveness; HORIZON 2020 EU DynaHEALTH Project 633595; Fundación Carolina, Madrid, Spain; Catedra ORDESA-University of Granada, Spain as part of Special Issue "Early Nutrition and Re-programming of Health and Disease"
Although early life nutrition influences brain development and mental health, the long-term e ects of supplemented infant formula on children´s behavior remain unclear. We analyzed the e ects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Di erent statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological a ective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial e ects on internalizing and total problem rate in their o spring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development.