@misc{10481/66557,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/66557},
abstract = {Although early life nutrition influences brain development and mental health, the long-term
e ects of supplemented infant formula on children´s behavior remain unclear. We analyzed the e ects
of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to
a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a
standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41),
during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating
in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at
18 months and 2.5 years. Di erent statistical analyses were performed using SPSS. EF children aged
2.5 years presented fewer pathological a ective problems than SF children. Besides, SF children
were classified more frequently as bordering on internalizing problems than BF children. Rates of
externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal
IQ was found to have beneficial e ects on internalizing and total problem rate in their o spring at
18 months of life; finally, higher maternal educational level was related with fewer ADHD problems
in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children
aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer
behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children
behavioral development.},
organization = {Ordesa Laboratories},
organization = {S.L. Contract University of Granada General Foundation 	
3349},
organization = {SMARTFOODS (CIEN) Contract University of Granada General Foundation 	
4003},
organization = {Spanish Ministry of Economy, Industry and Competitiveness},
organization = {HORIZON 2020 EU DynaHEALTH Project 	
633595},
organization = {Fundación Carolina, Madrid, Spain},
organization = {Catedra ORDESA-University of Granada, Spain as part of Special Issue "Early Nutrition and Re-programming of Health and Disease"},
publisher = {Mdpi},
keywords = {Infant formula},
keywords = {Milk fat globule membrane},
keywords = {Long chain polyunsaturated fatty acids},
keywords = {Bioactive compounds},
keywords = {Children behavior},
keywords = {Breastfeeding},
title = {The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study},
doi = {10.3390/nu12123825},
author = {Nieto Ruiz, Ana María and Diéguez Castillo, Estefanía and Sepúlveda Valbuena, Natalia and Herrmann, Florian and Cerdó, Tomás and López Torrecillas, Francisca and Pérez García, Miguel and Miranda León, María Teresa and Catena Martínez, Andrés and García Santos, José Antonio and García Bermúdez, María Mercedes and Campoy Folgoso, Cristina},
}