The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study Nieto Ruiz, Ana María Diéguez Castillo, Estefanía Sepúlveda Valbuena, Natalia Herrmann, Florian Cerdó, Tomás López Torrecillas, Francisca Pérez García, Miguel Miranda León, María Teresa Catena Martínez, Andrés García Santos, José Antonio García Bermúdez, María Mercedes Campoy Folgoso, Cristina Infant formula Milk fat globule membrane Long chain polyunsaturated fatty acids Bioactive compounds Children behavior Breastfeeding Although early life nutrition influences brain development and mental health, the long-term e ects of supplemented infant formula on children´s behavior remain unclear. We analyzed the e ects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Di erent statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological a ective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial e ects on internalizing and total problem rate in their o spring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development. 2021-02-15T10:22:55Z 2021-02-15T10:22:55Z 2020-12-15 info:eu-repo/semantics/article Nieto-Ruiz, A., Diéguez, E., Sepúlveda-Valbuena, N., Herrmann, F., Cerdó, T., López-Torrecillas, F., ... & Campoy, C. (2020). The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study. Nutrients, 12(12), 3825. [doi:10.3390/nu12123825] http://hdl.handle.net/10481/66557 10.3390/nu12123825 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Mdpi