Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy
Metadatos
Mostrar el registro completo del ítemAutor
Castillo Santaella, Teresa del; Yang, Yan; Martínez González, Inmaculada; Gálvez Ruiz, María José; Cabrerizo Vílchez, Miguel Ángel; Holgado Terriza, Juan Antonio; Selles Galiana, Fernando; Maldonado Valderrama, JuliaEditorial
MDPI
Materia
Polidocanol Foam Sclerotherapy Hyaluronic acid Poloxamer Surface tension Surface elasticity
Fecha
2020Referencia bibliográfica
del Castillo-Santaella, T.; Yang, Y.; Martínez-González, I.; Gálvez-Ruiz, M.J.; Cabrerizo-Vílchez, M.Á.; Holgado-Terriza, J.A.; Selles-Galiana, F.; Maldonado-Valderrama, J. Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy. Pharmaceutics 2020, 12, 1039. [DOI: 10.3390/pharmaceutics12111039]
Patrocinador
Junta de Andalucia NANOFOAM-PI12.2956; Instituto de Salud Carlos III Spanish Government MAT2017-82182-R RTI2018-101309-B-C21; Consejeria de Economia, Conocimiento, Empresas y Universidad; European Union (EU) SOMM17/6109/UGRResumen
The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics.
One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the
addition of bioactive compounds to improve the delivery system being a current subject of study.
This work shows the influence of two bioactive additives on the structure and stability of POL
foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer
present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with
plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam
stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced
the size and polydispersity of the bubble size distribution and increased the surface elasticity with
respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble
structure and increased surface elasticity, again contributing to the enhancement of foam stability.
The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to
assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the
target vein.