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dc.contributor.authorCastillo Santaella, Teresa del 
dc.contributor.authorYang, Yan
dc.contributor.authorMartínez González, Inmaculada
dc.contributor.authorGálvez Ruiz, María José 
dc.contributor.authorCabrerizo Vílchez, Miguel Ángel 
dc.contributor.authorHolgado Terriza, Juan Antonio 
dc.contributor.authorSelles Galiana, Fernando
dc.contributor.authorMaldonado Valderrama, Julia
dc.identifier.citationdel Castillo-Santaella, T.; Yang, Y.; Martínez-González, I.; Gálvez-Ruiz, M.J.; Cabrerizo-Vílchez, M.Á.; Holgado-Terriza, J.A.; Selles-Galiana, F.; Maldonado-Valderrama, J. Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy. Pharmaceutics 2020, 12, 1039. [DOI: 10.3390/pharmaceutics12111039]es_ES
dc.description.abstractThe use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics. One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the addition of bioactive compounds to improve the delivery system being a current subject of study. This work shows the influence of two bioactive additives on the structure and stability of POL foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced the size and polydispersity of the bubble size distribution and increased the surface elasticity with respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble structure and increased surface elasticity, again contributing to the enhancement of foam stability. The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the target vein.es_ES
dc.description.sponsorshipJunta de Andalucia NANOFOAM-PI12.2956es_ES
dc.description.sponsorshipInstituto de Salud Carlos III Spanish Government MAT2017-82182-R RTI2018-101309-B-C21es_ES
dc.description.sponsorshipConsejeria de Economia, Conocimiento, Empresas y Universidades_ES
dc.description.sponsorshipEuropean Union (EU) SOMM17/6109/UGRes_ES
dc.rightsAtribución 3.0 España*
dc.subjectHyaluronic acides_ES
dc.subjectSurface tensiones_ES
dc.subjectSurface elasticityes_ES
dc.titleEffect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapyes_ES

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Atribución 3.0 España
Except where otherwise noted, this item's license is described as Atribución 3.0 España