<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/65288">
      <dc:title>Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy</dc:title>
      <dc:creator>Castillo Santaella, Teresa del</dc:creator>
      <dc:creator>Yang, Yan</dc:creator>
      <dc:creator>Martínez González, Inmaculada</dc:creator>
      <dc:creator>Gálvez Ruiz, María José</dc:creator>
      <dc:creator>Cabrerizo Vílchez, Miguel Ángel</dc:creator>
      <dc:creator>Holgado Terriza, Juan Antonio</dc:creator>
      <dc:creator>Selles Galiana, Fernando</dc:creator>
      <dc:creator>Maldonado Valderrama, Julia</dc:creator>
      <dc:subject>Polidocanol</dc:subject>
      <dc:subject>Foam</dc:subject>
      <dc:subject>Sclerotherapy</dc:subject>
      <dc:subject>Hyaluronic acid</dc:subject>
      <dc:subject>Poloxamer</dc:subject>
      <dc:subject>Surface tension</dc:subject>
      <dc:subject>Surface elasticity</dc:subject>
      <dc:description>The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics.&#xd;
One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the&#xd;
addition of bioactive compounds to improve the delivery system being a current subject of study.&#xd;
This work shows the influence of two bioactive additives on the structure and stability of POL&#xd;
foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer&#xd;
present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with&#xd;
plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam&#xd;
stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced&#xd;
the size and polydispersity of the bubble size distribution and increased the surface elasticity with&#xd;
respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble&#xd;
structure and increased surface elasticity, again contributing to the enhancement of foam stability.&#xd;
The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to&#xd;
assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the&#xd;
target vein.</dc:description>
      <dc:date>2021-01-08T09:58:22Z</dc:date>
      <dc:date>2021-01-08T09:58:22Z</dc:date>
      <dc:date>2020</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>del Castillo-Santaella, T.; Yang, Y.; Martínez-González, I.; Gálvez-Ruiz, M.J.; Cabrerizo-Vílchez, M.Á.; Holgado-Terriza, J.A.; Selles-Galiana, F.; Maldonado-Valderrama, J. Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy. Pharmaceutics 2020, 12, 1039. [DOI: 10.3390/pharmaceutics12111039]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/65288</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics12111039</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>