New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?
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AuthorMolina Morales, Nerea; Sola Leyva, Alberto; Sáez Lara, María José; Plaza Díaz, Julio; Romero, Barbara; Clavero, Ana; Mozas Moreno, Juan; Fontes, Juan; Altmäe, Signe
Molina, N. M., Sola-Leyva, A., Saez-Lara, M. J., Plaza-Diaz, J., Tubić-Pavlović, A., Romero, B., ... & Altmäe, S. (2020). New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?. Biomolecules, 10(4), 593. [doi:10.3390/biom10040593]
SponsorshipThis work is supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER): grants RYC-2016-21199 and ENDORE SAF2017-87526-R; Programa Operativo FEDER Andalucía (B-CTS-500-UGR18) and by the University of Granada Plan Propio de Investigación 2016—Excellence actions: Unit of Excellence on Exercise and Health (UCEES)—and Plan Propio de Investigación 2018—Programa Contratos-Puente, and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds (ref. SOMM17/6107/UGR). A.S.-L. is funded by the Spanish Ministry of Science, Innovation and Universities (PRE2018-0854409).
Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Nevertheless there is no unified protocol for assessing the endometrial dysbiosis and no optimal treatment protocol for the established dysbiosis. With this review we outline the microbes (mostly bacteria) identified in the endometrial microbiome studies, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition.