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dc.contributor.authorMolina Morales, Nerea 
dc.contributor.authorSola Leyva, Alberto 
dc.contributor.authorSáez Lara, María José 
dc.contributor.authorPlaza Díaz, Julio 
dc.contributor.authorRomero, Barbara
dc.contributor.authorClavero Gilabert, Ana
dc.contributor.authorMozas Moreno, Juan 
dc.contributor.authorFontes, Juan
dc.contributor.authorAltmae, Signe 
dc.date.accessioned2020-07-15T11:48:49Z
dc.date.available2020-07-15T11:48:49Z
dc.date.issued2020-04
dc.identifier.citationMolina, N. M., Sola-Leyva, A., Saez-Lara, M. J., Plaza-Diaz, J., Tubić-Pavlović, A., Romero, B., ... & Altmäe, S. (2020). New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?. Biomolecules, 10(4), 593. [doi:10.3390/biom10040593]es_ES
dc.identifier.urihttp://hdl.handle.net/10481/62986
dc.descriptionWe acknowledge the research support by Copan Italia S.p.A Inc., and Clearblue, SPD Swiss Precision Diagnostics GmbH. This study is part of a PhD Thesis conducted at the Official Doctoral Programme in Biomedicine of the University of Granada, Spain. We are grateful to Ana Yara Postigo-Fuentes for her assistance with English language.es_ES
dc.description.abstractCurrent knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Nevertheless there is no unified protocol for assessing the endometrial dysbiosis and no optimal treatment protocol for the established dysbiosis. With this review we outline the microbes (mostly bacteria) identified in the endometrial microbiome studies, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition.es_ES
dc.description.sponsorshipThis work is supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER): grants RYC-2016-21199 and ENDORE SAF2017-87526-R; Programa Operativo FEDER Andalucía (B-CTS-500-UGR18) and by the University of Granada Plan Propio de Investigación 2016—Excellence actions: Unit of Excellence on Exercise and Health (UCEES)—and Plan Propio de Investigación 2018—Programa Contratos-Puente, and the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, European Regional Development Funds (ref. SOMM17/6107/UGR). A.S.-L. is funded by the Spanish Ministry of Science, Innovation and Universities (PRE2018-0854409).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAntibiotics es_ES
dc.subjectChronic endometritises_ES
dc.subjectEndometriosises_ES
dc.subjectEndometriumes_ES
dc.subjectMicrobiomees_ES
dc.subjectMicrobiotaes_ES
dc.subjectPrebioticses_ES
dc.subjectProbioticses_ES
dc.subjectUterus es_ES
dc.titleNew Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?es_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/biom10040593


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