Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers
Metadatos
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Carrión García, Cayetano Javier; Guerra Hernández, Eduardo Jesús; García Villanova Ruiz, Belén; Serafini, Mauro; Sánchez Pérez, María José; Molina Montes, María EsterEditorial
MDPI
Materia
Total antioxidant capacity Dietary antioxidants Antioxidant status Oxidative stress Inflammatory markers
Fecha
2020-04Referencia bibliográfica
Carrión-García, C. J., Guerra-Hernández, E. J., García-Villanova, B., Serafini, M., Sánchez, M. J., Amiano, P., & Molina-Montes, E. (2020). Plasma Non-Enzymatic Antioxidant Capacity (NEAC) in Relation to Dietary NEAC, Nutrient Antioxidants and Inflammation-Related Biomarkers. Antioxidants, 9(4), 301. [doi:10.3390/antiox9040301]
Patrocinador
This research was co-funded by the Health Research Found (FIS), Acción Estratégica en Salud (AES), of the Spanish Ministry of Economy and Competitiveness, grant number PI12/00002, and the European Regional Development Fund (ERDF).Resumen
(1) Background: Little is known about the interlinkages between dietary and plasma
non-enzymatic antioxidant capacity (D-NEAC and P-NEAC, respectively) and the body’s antioxidant
and inflammation response. Our aim was to explore these associations in 210 participants from two
Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) centers. (2) Methods:
D-NEAC was estimated using published NEAC values in food. P-NEAC and total polyphenols
(TP) were quantified by FRAP (ferric-reducing antioxidant power), TRAP (total radical-trapping
antioxidant parameter), TEAC-ABTS (trolox equivalent antioxidant capacity-Azino Bis Thiazoline
Sulfonic), ORAC (oxygen radical absorbance capacity) and Folin–Ciocalteu assays. Nutrient antioxidants
(carotenes, α-tocopherol, ascorbic acid, retinol, uric acid, Q9 and Q10 coenzymes) and inflammation
markers (IL-6, IL-8, CRP, TNF-α, PAI-I, resistin and adiponectin) were also analyzed. Spearman correlation
and linear regression analyses were performed in association analyses. Analyses were stratified by
covariates and groups were defined using cluster analysis. (3) Results: P-FRAP was correlated with
D-NEAC, and significantly associated with P-NEAC in multivariate adjusted models. P-FRAP levels
were also significantly associated with plasma antioxidants (log2 scale: TP β = 0.26; ascorbic acid
β = 0.03; retinol β = 0.08; α-tocopherol β = 0.05; carotenes β = 0.02; Q10 β = 0.06; uric acid β = 0.25),
though not with inflammation-related biomarkers. Different profiles of individuals with varying levels
of P-NEAC and biomarkers were found. (4) Conclusions: P-NEAC levels were to some extent associated
with D-NEAC and plasma antioxidants, yet not associated with inflammation response.
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