Neutron radiobiology studies with a pure cold neutron beam
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AuthorPedrosa-Rivera, María; Ruiz-Magaña, María José; Porras Sánchez, José Ignacio; Praena Rodríguez, Antonio Javier; Torres-Sánchez, P.; Sabariego, M. P.; Ruiz Ruiz, María Carmen
Neutron radiobiologyCold neutron beamA375 melanoma cellsBNCT
Pedrosa-Rivera, M., Ruiz-Magaña, M. J., Porras, I., Praena, J., Torres-Sánchez, P., Sabariego, M. P., ... & Ruiz-Ruiz, C. (2020). Neutron radiobiology studies with a pure cold neutron beam. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 462, 24-31.
SponsorshipWe acknowledge financial support for this work from the Fundación Científica de la Asociación Española Contra el Cáncer (AECC) under grant PS16163811PORR, Junta de Andalucía (Andalusian Regional Government), under contract P11-FQM-8229, Spanish MINECO and FEDER funds under contract FIS2015-69941-C2-1-P, the grant agreement ILL-UGR and the founders of the University of Granada Chair Neutrons for Medicine: Spanish Fundación ACS and Capitán Antonio. M.P. acknowledges a grant under the program Becas de Iniciación a la Investigación from the Universidad de Granada (Plan Propio de Investigación). The open access fee was covered by FILL2030, a European Union project within the European Commission’s Horizon 2020 Research and Innovation programme under grant agreement N°731096.
Data on the radiobiological effects of thermal neutrons are usually obtained from irradiations in a mixed field of neutrons of different energies and gamma rays or from conversion of proton data with similar energies to those created in the neutron capture on nitrogen. Experimental data from irradiations in a pure thermal or cold neutron beam can help to find new values for neutron relative biological effectiveness (RBE) factors, which are useful for BNCT (Boron Neutron Capture Therapy) and radiation protection applications. We present a new experimental setup for radiobiological studies at a cold neutron beam at Institut Laue-Langevin, a beam without fast neutron component and almost no gamma ray contribution. After the irradiation, survival assays are performed to obtain the survival curves. Finally, comparing with a reference photon irradiation, the thermal neutron RBE factors can be calculated. The methodology is outlined at the example of A375 melanoma cells for which new radiobiological data were obtained.