Neutron radiobiology studies with a pure cold neutron beam
Metadatos
Mostrar el registro completo del ítemAutor
Pedrosa-Rivera, María; Ruiz-Magaña, María José; Porras Sánchez, José Ignacio; Praena Rodríguez, Antonio Javier; Torres Sánchez, Pablo; Sabariego, M. P.; Ruiz Ruiz, María CarmenEditorial
Elsevier BV
Materia
Neutron radiobiology Cold neutron beam A375 melanoma cells BNCT
Fecha
2019-11-08Referencia bibliográfica
Pedrosa-Rivera, M., Ruiz-Magaña, M. J., Porras, I., Praena, J., Torres-Sánchez, P., Sabariego, M. P., ... & Ruiz-Ruiz, C. (2020). Neutron radiobiology studies with a pure cold neutron beam. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 462, 24-31.
Patrocinador
We acknowledge financial support for this work from the Fundación Científica de la Asociación Española Contra el Cáncer (AECC) under grant PS16163811PORR, Junta de Andalucía (Andalusian Regional Government), under contract P11-FQM-8229, Spanish MINECO and FEDER funds under contract FIS2015-69941-C2-1-P, the grant agreement ILL-UGR and the founders of the University of Granada Chair Neutrons for Medicine: Spanish Fundación ACS and Capitán Antonio. M.P. acknowledges a grant under the program Becas de Iniciación a la Investigación from the Universidad de Granada (Plan Propio de Investigación). The open access fee was covered by FILL2030, a European Union project within the European Commission’s Horizon 2020 Research and Innovation programme under grant agreement N°731096.Resumen
Data on the radiobiological effects of thermal neutrons are usually obtained from irradiations in a mixed field of
neutrons of different energies and gamma rays or from conversion of proton data with similar energies to those
created in the neutron capture on nitrogen. Experimental data from irradiations in a pure thermal or cold
neutron beam can help to find new values for neutron relative biological effectiveness (RBE) factors, which are
useful for BNCT (Boron Neutron Capture Therapy) and radiation protection applications. We present a new
experimental setup for radiobiological studies at a cold neutron beam at Institut Laue-Langevin, a beam without
fast neutron component and almost no gamma ray contribution. After the irradiation, survival assays are performed
to obtain the survival curves. Finally, comparing with a reference photon irradiation, the thermal
neutron RBE factors can be calculated. The methodology is outlined at the example of A375 melanoma cells for
which new radiobiological data were obtained.