Neutron radiobiology studies with a pure cold neutron beam Pedrosa-Rivera, María Ruiz-Magaña, María José Porras Sánchez, José Ignacio Praena Rodríguez, Antonio Javier Torres Sánchez, Pablo Sabariego, M. P. Ruiz Ruiz, María Carmen Neutron radiobiology Cold neutron beam A375 melanoma cells BNCT Data on the radiobiological effects of thermal neutrons are usually obtained from irradiations in a mixed field of neutrons of different energies and gamma rays or from conversion of proton data with similar energies to those created in the neutron capture on nitrogen. Experimental data from irradiations in a pure thermal or cold neutron beam can help to find new values for neutron relative biological effectiveness (RBE) factors, which are useful for BNCT (Boron Neutron Capture Therapy) and radiation protection applications. We present a new experimental setup for radiobiological studies at a cold neutron beam at Institut Laue-Langevin, a beam without fast neutron component and almost no gamma ray contribution. After the irradiation, survival assays are performed to obtain the survival curves. Finally, comparing with a reference photon irradiation, the thermal neutron RBE factors can be calculated. The methodology is outlined at the example of A375 melanoma cells for which new radiobiological data were obtained. 2020-01-15T08:55:38Z 2020-01-15T08:55:38Z 2019-11-08 info:eu-repo/semantics/article Pedrosa-Rivera, M., Ruiz-Magaña, M. J., Porras, I., Praena, J., Torres-Sánchez, P., Sabariego, M. P., ... & Ruiz-Ruiz, C. (2020). Neutron radiobiology studies with a pure cold neutron beam. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 462, 24-31. http://hdl.handle.net/10481/58757 10.1016/j.nimb.2019.10.027 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Elsevier BV