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dc.contributor.authorAcosta Manzano, Pedro 
dc.contributor.authorColl Risco, Irene
dc.contributor.authorVan Poppel, Mireille N. M.
dc.contributor.authorSegura Jiménez, Víctor
dc.contributor.authorFemia Marzo, Pedro Jesús 
dc.contributor.authorRomero Gallardo, Lidia
dc.contributor.authorBorges-Cosic, Milkana
dc.contributor.authorDíaz Castro, Javier 
dc.contributor.authorMoreno-Fernández, Jorge
dc.contributor.authorOchoa Herrera, Julio José 
dc.contributor.authorAparicio García-Molina, Virginia
dc.identifier.citationAcosta-Manzano, P., Coll-Risco, I., Van Poppel, M. N., Segura-Jiménez, V., Femia, P., Romero-Gallardo, L., ... & Aparicio, V. A. (2019). Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project. Journal of clinical medicine, 8(11), 1862.es_ES
dc.description.abstractThe aim of the present study was to analyze the influence of a supervised concurrent exercise-training program, from the 17th gestational week until delivery, on cytokines in maternal (at 17th and 35th gestational week, and at delivery) and arterial and venous cord serum. Fifty-eight Caucasian pregnant women (age: 33.5 4.7 years old, body mass index: 23.6 4.1kg/m2) from the GESTAFIT Project (exercise (n = 37) and control (n = 21) groups) participated in this quasi-experimental study (per-protocol basis). The exercise group followed a 60-min 3 days/week concurrent (aerobic-resistance) exercise-training from the 17th gestational week to delivery. Maternal and arterial and venous cord serum cytokines (fractalkine, interleukin (IL)–1 , IL-6, IL-8, IL-10, interferon (IFN)– , and tumor necrosis factor (TNF)–alpha) were assessed using Luminex xMAP technology. In maternal serum (after adjusting for the baseline values of cytokines), the exercise group decreased TNF-alpha (from baseline to 35th week, p = 0.02), and increased less IL-1 (from baseline to delivery, p = 0.03) concentrations than controls. When adjusting for other potential confounders, these di erences became non-significant. In cord blood, the exercise group showed reduced arterial IL-6 and venous TNF-alpha (p = 0.03 and p = 0.001, respectively) and higher concentrations of arterial IL-1 (p = 0.03) compared to controls. The application of concurrent exercise-training programs could be a strategy to modulate immune responses in pregnant women and their fetuses. However, future research is needed to better understand the origin and clearance of these cytokines, their role in the maternal-placental-fetus crosstalk, and the influence of exercise interventions on them.es_ES
dc.description.sponsorshipThis study was part of VAA fellowship from the Andalucía Talent-Hub Program, launched by the Andalusian Knowledge Agency, co-funded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND–Grant Agreement nº291780) and the Junta de Andalucía. This study has been also partially funded by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR.es_ES
dc.rightsAtribución 3.0 España*
dc.subjectImmune systemes_ES
dc.subjectCytokines es_ES
dc.subjectInterleukin 1Bes_ES
dc.subjectInterleukin 6es_ES
dc.subjectTumor necrosis factores_ES
dc.titleInfluence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Projectes_ES

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Atribución 3.0 España
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