Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project
Metadatos
Afficher la notice complèteAuteur
Acosta Manzano, Pedro; Coll Risco, Irene; Van Poppel, Mireille N. M.; Segura Jiménez, Víctor; Femia Marzo, Pedro Jesús; Romero Gallardo, Lidia; Borges-Cosic, Milkana; Díaz Castro, Javier; Moreno Fernández, Jorge; Ochoa Herrera, Julio José; Aparicio García-Molina, VirginiaEditorial
MDPI
Materia
Immune system Cytokines Interleukin 1B Interleukin 6 Interferon-gamma Tumor necrosis factor
Date
2019-11-03Referencia bibliográfica
Acosta-Manzano, P., Coll-Risco, I., Van Poppel, M. N., Segura-Jiménez, V., Femia, P., Romero-Gallardo, L., ... & Aparicio, V. A. (2019). Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project. Journal of clinical medicine, 8(11), 1862.
Patrocinador
This study was part of VAA fellowship from the Andalucía Talent-Hub Program, launched by the Andalusian Knowledge Agency, co-funded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND–Grant Agreement nº291780) and the Junta de Andalucía. This study has been also partially funded by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR.Résumé
The aim of the present study was to analyze the influence of a supervised concurrent
exercise-training program, from the 17th gestational week until delivery, on cytokines in maternal
(at 17th and 35th gestational week, and at delivery) and arterial and venous cord serum. Fifty-eight
Caucasian pregnant women (age: 33.5 4.7 years old, body mass index: 23.6 4.1kg/m2)
from the GESTAFIT Project (exercise (n = 37) and control (n = 21) groups) participated in this
quasi-experimental study (per-protocol basis). The exercise group followed a 60-min 3 days/week
concurrent (aerobic-resistance) exercise-training from the 17th gestational week to delivery. Maternal
and arterial and venous cord serum cytokines (fractalkine, interleukin (IL)–1 , IL-6, IL-8, IL-10,
interferon (IFN)–
, and tumor necrosis factor (TNF)–alpha) were assessed using Luminex xMAP
technology. In maternal serum (after adjusting for the baseline values of cytokines), the exercise
group decreased TNF-alpha (from baseline to 35th week, p = 0.02), and increased less IL-1 (from baseline
to delivery, p = 0.03) concentrations than controls. When adjusting for other potential confounders,
these di erences became non-significant. In cord blood, the exercise group showed reduced arterial
IL-6 and venous TNF-alpha (p = 0.03 and p = 0.001, respectively) and higher concentrations of arterial
IL-1 (p = 0.03) compared to controls. The application of concurrent exercise-training programs could
be a strategy to modulate immune responses in pregnant women and their fetuses. However, future
research is needed to better understand the origin and clearance of these cytokines, their role in the
maternal-placental-fetus crosstalk, and the influence of exercise interventions on them.