Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project
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AuthorAcosta-Manzano, Pedro; Coll Risco, Irene; Van Poppel, Mireille N. M.; Segura Jiménez, Víctor; Femia Marzo, Pedro Jesús; Romero Gallardo, Lidia; Borges-Cosic, Milkana; Díaz Castro, Javier; Moreno-Fernández, Jorge; Ochoa Herrera, Julio José; Aparicio García-Molina, Virginia
Immune systemCytokinesInterleukin 1BInterleukin 6Interferon-gammaTumor necrosis factor
Acosta-Manzano, P., Coll-Risco, I., Van Poppel, M. N., Segura-Jiménez, V., Femia, P., Romero-Gallardo, L., ... & Aparicio, V. A. (2019). Influence of a Concurrent Exercise Training Intervention during Pregnancy on Maternal and Arterial and Venous Cord Serum Cytokines: The GESTAFIT Project. Journal of clinical medicine, 8(11), 1862.
SponsorshipThis study was part of VAA fellowship from the Andalucía Talent-Hub Program, launched by the Andalusian Knowledge Agency, co-funded by the European Union’s Seventh Framework Program, Marie Skłodowska-Curie actions (COFUND–Grant Agreement nº291780) and the Junta de Andalucía. This study has been also partially funded by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR.
The aim of the present study was to analyze the influence of a supervised concurrent exercise-training program, from the 17th gestational week until delivery, on cytokines in maternal (at 17th and 35th gestational week, and at delivery) and arterial and venous cord serum. Fifty-eight Caucasian pregnant women (age: 33.5 4.7 years old, body mass index: 23.6 4.1kg/m2) from the GESTAFIT Project (exercise (n = 37) and control (n = 21) groups) participated in this quasi-experimental study (per-protocol basis). The exercise group followed a 60-min 3 days/week concurrent (aerobic-resistance) exercise-training from the 17th gestational week to delivery. Maternal and arterial and venous cord serum cytokines (fractalkine, interleukin (IL)–1 , IL-6, IL-8, IL-10, interferon (IFN)– , and tumor necrosis factor (TNF)–alpha) were assessed using Luminex xMAP technology. In maternal serum (after adjusting for the baseline values of cytokines), the exercise group decreased TNF-alpha (from baseline to 35th week, p = 0.02), and increased less IL-1 (from baseline to delivery, p = 0.03) concentrations than controls. When adjusting for other potential confounders, these di erences became non-significant. In cord blood, the exercise group showed reduced arterial IL-6 and venous TNF-alpha (p = 0.03 and p = 0.001, respectively) and higher concentrations of arterial IL-1 (p = 0.03) compared to controls. The application of concurrent exercise-training programs could be a strategy to modulate immune responses in pregnant women and their fetuses. However, future research is needed to better understand the origin and clearance of these cytokines, their role in the maternal-placental-fetus crosstalk, and the influence of exercise interventions on them.