Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults
Metadatos
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Sánchez-Delgado, Guillermo; Martínez Téllez, Borja Manuel; García Rivero, Yolanda; Acosta Manzano, Francisco Miguel; Amaro Gahete, Francisco José; Alcantara, Juan M.A.; Llamas Elvira, José Manuel; Ruiz Ruiz, JonatanEditorial
Frontiers Media
Materia
Brown fat Non-shivering thermogenesis Energy expenditure Energy balance Obesity
Fecha
2018-11-16Referencia bibliográfica
Sanchez-Delgado G, Martinez-Tellez B, Garcia-Rivero Y, Alcantara JMA, Acosta FM, Amaro-Gahete FJ, Llamas-Elvira JM and Ruiz JR (2018) Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults. Front. Physiol. 9:1577.
Patrocinador
The study was supported by the Spanish Ministry of Economy and Competitiveness (PTA 12264-I), Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393), and Retos de la Sociedad (DEP2016-79512-R), Fondos EstructuralesResumen
Cold induced thermogenesis (CIT) in humans results mainly from the combination
of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The
relative contribution of both tissues to CIT and to cold induced nutrient oxidation
rates (CI-NUTox) remains, however, to be elucidated. We investigated the association
of BAT and skeletal muscle activity after a personalized cold exposure with CIT
and CI-NUTox in 57 healthy adults (23.0 2.4 years old; 25.1 4.6 kg/m2; 35
women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus
colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and
triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose
positron emission tomography-computed tomography scan preceded by a personalized
cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at
19.5–20 C wearing a water perfused cooling vest set at 3.8 C above the individual
shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect
calorimetry under fasting conditions for 1 h of personalized cold exposure. There was
no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2).