Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults Sánchez-Delgado, Guillermo Martínez Téllez, Borja Manuel García Rivero, Yolanda Acosta Manzano, Francisco Miguel Amaro Gahete, Francisco José Alcantara, Juan M.A. Llamas Elvira, José Manuel Ruiz Ruiz, Jonatan Brown fat Non-shivering thermogenesis Energy expenditure Energy balance Obesity Cold induced thermogenesis (CIT) in humans results mainly from the combination of both brown adipose tissue (BAT) and skeletal muscle thermogenic activity. The relative contribution of both tissues to CIT and to cold induced nutrient oxidation rates (CI-NUTox) remains, however, to be elucidated. We investigated the association of BAT and skeletal muscle activity after a personalized cold exposure with CIT and CI-NUTox in 57 healthy adults (23.0 2.4 years old; 25.1 4.6 kg/m2; 35 women). BAT and skeletal muscle (paracervical, sternocleidomastoid, scalene, longus colli, trapezius, parathoracic, supraspinatus, subscapular, deltoid, pectoralis major, and triceps brachii) metabolic activity were assessed by means of a 18Fluorodeoxyglucose positron emission tomography-computed tomography scan preceded by a personalized cold exposure. The cold exposure consisted in remaining in a mild cold room for 2 h at 19.5–20 C wearing a water perfused cooling vest set at 3.8 C above the individual shivering threshold. On a separate day, we estimated CIT and CI-NUTox by indirect calorimetry under fasting conditions for 1 h of personalized cold exposure. There was no association of BAT volume or activity with CIT or CI-NUTox (all P > 0.2). 2019-10-29T12:39:03Z 2019-10-29T12:39:03Z 2018-11-16 journal article Sanchez-Delgado G, Martinez-Tellez B, Garcia-Rivero Y, Alcantara JMA, Acosta FM, Amaro-Gahete FJ, Llamas-Elvira JM and Ruiz JR (2018) Brown Adipose Tissue and Skeletal Muscle 18F-FDG Activity After a Personalized Cold Exposure Is Not Associated With Cold-Induced Thermogenesis and Nutrient Oxidation Rates in Young Healthy Adults. Front. Physiol. 9:1577. http://hdl.handle.net/10481/57590 10.3389/fphys.2018.01577 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Frontiers Media