Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal
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MDPI
Materia
Adsorption Carbon xerogel microspheres (CXMs) In vitro conditions
Fecha
2019-09-19Referencia bibliográfica
Cortés, F. B., Zapata, K., Rojano, B. A., Carrasco-Marín, F., Gallego, J., Hernández, M. A., & Franco, C. A. (2019). Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal. Molecules, 24(18), 3398.
Patrocinador
The authors thank Colciencias for financing the doctoral studies of Karol Zapata Acosta through the announcement 617/2014. The authors also thank Colciencias and the Agencia Nacional de Hidrocarburos (ANH) for the support provided in Agreement 064-2018Resumen
The main objective of this study is to develop a novel dual-purpose material based on
carbon xerogel microspheres (CXMs) that permits the delayed release of cannabidiol (CBD) and
the removal of aflatoxin. The CXMs were prepared by the sol-gel method and functionalized with
phosphoric acid (CXMP) and melamine (CXMN). The support and the modified materials were
characterized by scanning electronic microscopy (SEM),N2 adsorption at -196 C, X-ray photoelectron
spectroscopy (XPS), and zeta potential. For the loading of the cannabidiol (CBD) in the porous
samples, batch–mode adsorption experiments at 25 C were performed, varying the concentration
of CBD. The desorption kinetics was performed at two conditions for simulating the gastric (pH
of 2.1) and intestinal (pH of 7.4) conditions at 37 C based on in vitro CBD release. Posteriorly,
the samples obtained after desorption were used to study aflatoxin removal, which was evaluated
through adsorption experiments at pH = 7.4 and 37 C. The adsorption isotherms of CBD showed
a type I(b) behavior, with the adsorbed uptake being higher for the support than for the modified
materials with P and N. Meanwhile, the desorption kinetics of CBD at gastric conditions indicated
release values lower than 8%, and the remaining amount was desorbed at pH = 7.4 in three hours
until reaching 100% based on the in vitro experiments. The results for aflatoxin showed total removal
in less than 30 min for all the materials evaluated. This study opens a broader landscape in which to
develop dual-purpose materials for the delayed release of CBD, improving its bioavailability and
allowing aflatoxin removal in gastric conditions.