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dc.contributor.authorCortés, Farid
dc.contributor.authorCarrasco Marín, Francisco 
dc.date.accessioned2019-10-23T09:44:44Z
dc.date.available2019-10-23T09:44:44Z
dc.date.issued2019-09-19
dc.identifier.citationCortés, F. B., Zapata, K., Rojano, B. A., Carrasco-Marín, F., Gallego, J., Hernández, M. A., & Franco, C. A. (2019). Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal. Molecules, 24(18), 3398.es_ES
dc.identifier.urihttp://hdl.handle.net/10481/57472
dc.description.abstractThe main objective of this study is to develop a novel dual-purpose material based on carbon xerogel microspheres (CXMs) that permits the delayed release of cannabidiol (CBD) and the removal of aflatoxin. The CXMs were prepared by the sol-gel method and functionalized with phosphoric acid (CXMP) and melamine (CXMN). The support and the modified materials were characterized by scanning electronic microscopy (SEM),N2 adsorption at -196 C, X-ray photoelectron spectroscopy (XPS), and zeta potential. For the loading of the cannabidiol (CBD) in the porous samples, batch–mode adsorption experiments at 25 C were performed, varying the concentration of CBD. The desorption kinetics was performed at two conditions for simulating the gastric (pH of 2.1) and intestinal (pH of 7.4) conditions at 37 C based on in vitro CBD release. Posteriorly, the samples obtained after desorption were used to study aflatoxin removal, which was evaluated through adsorption experiments at pH = 7.4 and 37 C. The adsorption isotherms of CBD showed a type I(b) behavior, with the adsorbed uptake being higher for the support than for the modified materials with P and N. Meanwhile, the desorption kinetics of CBD at gastric conditions indicated release values lower than 8%, and the remaining amount was desorbed at pH = 7.4 in three hours until reaching 100% based on the in vitro experiments. The results for aflatoxin showed total removal in less than 30 min for all the materials evaluated. This study opens a broader landscape in which to develop dual-purpose materials for the delayed release of CBD, improving its bioavailability and allowing aflatoxin removal in gastric conditions.es_ES
dc.description.sponsorshipThe authors thank Colciencias for financing the doctoral studies of Karol Zapata Acosta through the announcement 617/2014. The authors also thank Colciencias and the Agencia Nacional de Hidrocarburos (ANH) for the support provided in Agreement 064-2018es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAdsorption es_ES
dc.subjectCarbon xerogel microspheres (CXMs)es_ES
dc.subjectIn vitro conditionses_ES
dc.titleDual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removales_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.doi10.3390/molecules24183398


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Atribución 3.0 España
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