<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/57472">
      <dc:title>Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal</dc:title>
      <dc:creator>Cortés, Farid</dc:creator>
      <dc:creator>Carrasco Marín, Francisco</dc:creator>
      <dc:subject>Adsorption</dc:subject>
      <dc:subject>Carbon xerogel microspheres (CXMs)</dc:subject>
      <dc:subject>In vitro conditions</dc:subject>
      <dc:description>The main objective of this study is to develop a novel dual-purpose material based on&#xd;
 carbon xerogel microspheres (CXMs) that permits the delayed release of cannabidiol (CBD) and&#xd;
 the removal of aflatoxin. The CXMs were prepared by the sol-gel method and functionalized with&#xd;
 phosphoric acid (CXMP) and melamine (CXMN). The support and the modified materials were&#xd;
 characterized by scanning electronic microscopy (SEM),N2 adsorption at -196 C, X-ray photoelectron&#xd;
 spectroscopy (XPS), and zeta potential. For the loading of the cannabidiol (CBD) in the porous&#xd;
 samples, batch–mode adsorption experiments at 25 C were performed, varying the concentration&#xd;
 of CBD. The desorption kinetics was performed at two conditions for simulating the gastric (pH&#xd;
 of 2.1) and intestinal (pH of 7.4) conditions at 37 C based on in vitro CBD release. Posteriorly,&#xd;
 the samples obtained after desorption were used to study aflatoxin removal, which was evaluated&#xd;
 through adsorption experiments at pH = 7.4 and 37 C. The adsorption isotherms of CBD showed&#xd;
 a type I(b) behavior, with the adsorbed uptake being higher for the support than for the modified&#xd;
 materials with P and N. Meanwhile, the desorption kinetics of CBD at gastric conditions indicated&#xd;
 release values lower than 8%, and the remaining amount was desorbed at pH = 7.4 in three hours&#xd;
 until reaching 100% based on the in vitro experiments. The results for aflatoxin showed total removal&#xd;
 in less than 30 min for all the materials evaluated. This study opens a broader landscape in which to&#xd;
 develop dual-purpose materials for the delayed release of CBD, improving its bioavailability and&#xd;
 allowing aflatoxin removal in gastric conditions.</dc:description>
      <dc:date>2019-10-23T09:44:44Z</dc:date>
      <dc:date>2019-10-23T09:44:44Z</dc:date>
      <dc:date>2019-09-19</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Cortés, F. B., Zapata, K., Rojano, B. A., Carrasco-Marín, F., Gallego, J., Hernández, M. A., &amp; Franco, C. A. (2019). Dual-Purpose Materials Based on Carbon Xerogel Microspheres (CXMs) for Delayed Release of Cannabidiol (CBD) and Subsequent Aflatoxin Removal. Molecules, 24(18), 3398.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/57472</dc:identifier>
      <dc:identifier>10.3390/molecules24183398</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>